A disease of the elderly with higher incidence in gallstone disease, porcelain gallbladder and large polyps / adenomyosis. Incidence higher in North India especially along the Gangetic basin (industrial toxins). Jaundice usually indicates an advanced disease and a dismal prognosis. Prognosis is best for early GBC, which are resected. Surgery varies from a radial cholecystectomy. (GB + lymphadenectomy + liver tissue from GB base) to segmental hepatectomy (4a +5) to extended hepatectomy. (Right trisegmentectomy) for advanced disease
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